The heterogeneity of platelet size is related with their functional and metabolic activity.
Young platelets are larger, denser and more active than the old ones.
Recently, coulter counter model S plus Ⅱ was introduced and could calculate the platelet distribution width (PDW).
Therefore this study was planned to evaluate the clinical significance of PDW in various hematologic diseases.
The results were summarized as follow :
1. There was nonlinear inverse relation between PDW and platelet count. PDW was increased in thrombocytopenic patient and decreased in thrombocytosis.
2. PDW was high as increasing WBC count in throiabocytopenic patient.
3. There was nonlinear relation between MPV and PDW in healthy person.
4. The diseases that disclosed normal MPVand normal PDW: pure red cell aplasia, hemolytic anemia.
5. The diseases that disclosed normal MPV ana high PDW: Polycythemia vela, Erythroid hyperplasia.
6. The diseases that disclosed low MPV and normal PDW: Hypoplastic marrow, Metastatic tumor and lead poisoning.
7. The diseases that disclosed low MPV and high PDW: AML, ALL, preleukemia and essential thrornbocythemia.
8. The diseases that disclosed high MPV and high PDW: Iron del. anemia, Reactive marrow.
9. The diseases that disclosed high MPV and low PDW: Idiopathic thromtocytopenic purpura.
|